zkMIPS is an advanced Zero-Knowledge Protocol(ZKP)system designed for MIPS architecture. zkMIPS ims to provide a verifiable com-puting solution to trust the computation results generated by untrusted computers.The adoption of the MIPS architecture aligns perfectly with the vision of incorpo-rating zkMIPS into diverse domains such as blockchains and IoT. In the blockchainrealm, zkMIPS is seamlessly integrated with blockchain Layer 2 technologies, offeringa ZKP layer 2 rollup solution. By harnessing the power of ZKP and leveraging therobustness of the MIPS architecture, zkMIPS aims to fulfill its objectives effectively.In non-blockchain systems including the Internet of Things (IoT), Virtual Reality (VR), decentralized cloud computing,and zero-knowledge machine learning (zkML)zkMIPS enables a secure communication channel by trusting devices' computationresults.