GenomesDAO

NIOME is subnet 55 on Bittensor, applying decentralised incentives to drug-response prediction research within the same ecosystem as a genomic data platform, which supplies DNA vaults, encrypted storage and on-chain access auditing, with $GENOME deployed on Base. It serves pharmacogenomics researchers, model developers and pharmaceutical companies, addressing real human genomes that privacy law and regulation keep from circulating at scale, and biomedical models constrained by data monopolies at a few institutions.

Validators generate synthetic genomic profiles with biological constraints, inject known genotype-to-phenotype rules as ground truth and publish tasks to miners, who submit predictions of drug efficacy and adverse-event risk; validators score accuracy and commit weights on-chain, which convert into emissions. Because inputs are continuously randomised and mutated, models cannot pass by memorisation and must learn generalisable patterns. The first task focused on drug-metabolism genes such as CYP2D6. A February 2026 specification, version 1.1, set out task definitions and scoring rules, the first challenge has completed, and the second turned to haemoglobin variants and gene-editing outcome prediction.