LayerZero is an Omnichain Interoperability Protocol designed for lightweight message passing across chains. It provides authentic and guaranteed message delivery with configurable trustlessness, implemented as a set of gas-efficient, non-upgradable smart contracts.

Axelar is a decentralized cross-chain communication network, aiming to level-up interoperability in Web3 by connecting heterogeneous blockchains and enabling asset mobility and program composability in an optimized way for both builders and end-users. The two layers of Axelar are the network and the API above it. At the core of Axelar is a permissionless overlay network that provides Turing-complete cross-chain communication through proof-of-stake and permissionless protocols. On top of the network are APIs and protocols, an application-development layer that developers use to compose across any number of chains. Once integrated, all new interconnected blockchains become interoperable with the application, resulting in limitless network effects.

Newton is a chain unification network jointly launched by Magic Labs and Polygon Labs, with a single wallet and balance across the chain. Newton is designed to boost interoperability across Polygon’s AggLayer, which connects layer-1 and layer-2 chains with shared liquidity. The network includes a wallet that lets users store and transfer various digital assets across various blockchain platforms with “simplified” cross-chain swaps.

Union is a yper-efficient interoperability protocol connects all blockchains and rollups, across any ecosystem. It's based on consensus verification and has no dependencies on trusted third parties, oracles, multi-signatures, or MPC.

Everclear is the new foundation of the chain abstraction stack, integrating with intent protocols, solver networks, modular blockchains, and dApps to enable the most efficient transaction settlement at the best possible price. Everclear coordinates the global settlement of liquidity between chains, solving fragmentation for modular blockchains.

GVNR is a General Message Passing Protocol that enables seamless connection between every compatible chain, peer-to-peer. GVNR is built for all users and especially AI Agents. GVNR enables permissionless universal control of all chains and all assets. GVNR can be deployed to any permissionless or permissioned blockchain, and will be self-deployable by chains, foundations or enterprises that wish to access the widest possible liquidity.

Dojima Network is creating an omnichain layer to bring the whole web3 ecosystem onto one common layer. It serves as a cross-chain hub, connecting various chains (both EVM and Non-EVM), pooling assets and data, and enabling the deployment of complex cross-chain applications. It provides a common ground for developers to access liquidity and interact with protocols from different blockchains.

TeleSwap is a trustless and universal interoperability protocol that provides developers with an infrastructure to build cross-chain applications. With it, users can transfer any data, such as messages, contract calls, tokens, or NFTs, between blockchains.

Quant is a cross-chain platform, and its main product, Overledger, is a DLT Gateway for businesses. Quant's platform is protocol-agnostic, simplifying and connecting any system to any network to any DLT anywhere in the world, allowing them to securely, simply and cost-effectively share, view, and exchange information and value. The Overledger Operating System from Quant Network automates trust functions between multiple blockchains. This system is designed to be a blockchain OS, with the goal of connecting blockchains and networks (such as those for financial services, healthcare, and more) on a global scale, while preserving interoperability.

Universal is a wrapped asset protocol designed to enable any token to trade on any chain. Universal can enhance liquidity management, simplify token availability across multiple chains, and significantly improve the overall user experience in crypto ecosystems.

Butter Network is an Omnichain Interoperability Hub integrated with ZK technology that enables users with global DAPP accessibility and data availability, building an infrastructure that makes transactions transverse across chain to chain freely and securely.

Diffuse is a zkServerless protocol dedicated to redefining trustless interoperability in Web3. By integrating decentralized and trustless principles with intuitive usability and cost-efficient scalability, it redefines the way protocols might communicate, effectively eliminating critical barriers such as slow proof generation, high verification costs, and complex infrastructure demands. zkServerless is an asynchronous computational layer for processing data from arbitrary origins, combining zero-knowledge proof technology with a serverless paradigm to enable trustless, automated, and scalable data processing and interactions without reliance on centralized infrastructure.

UNITS Network is an ecosystem of interconnected blockchain networks unified by shared economic incentives and consensus. Built on a consensus layer backed by beacon chain miners, it focuses on connecting networks and bootstrapping new sidechains.

Stripchain is a cross-chain interoperability protocol allows developers to create commands called intents to perform actions like transferring data between blockchains. Based on a system called stripVM, it will enable applications to communicate and coordinate with different protocols.

Beyond is a native Bitcoin L1 interoperability protocol, providing the necessary infrastructure for users to securely bridge any token to, from, and within Bitcoin L1.

Socket 2.0 is the first Chain Abstraction Protocol for Web3. It is a modular, extensible, and composable protocol that enables chain-agnostic applications. Socket abstracts away the underlying complexity of chains, allowing users to interact with applications without having to worry about the underlying chain.

oooo is a modular omnichain interoperability protocol supporting the Bitcoin ecosystem. Its modular communication protocol architecture ensures the integrity and reliability of data and transactions within the system. This approach resolves blockchain isolation and liquidity fragmentation, boosting capital efficiency and utilization, and ultimately improving the user experience. oooo is pioneering the next evolution in blockchain interoperability by introducing AI Omninet — an intelligent protocol that transforms cross-chain intents into seamless operations.

Genitive Network is a FHE (Fully Homomorphic Encryption) based BTC L2 interoperability protocol. Genitive Network, distinct from multi-signature bridges, utilizes FHE for EVM contract deployment with privacy computational capabilities, enabling fully onchain privacy while aligning with the security levels of BTC mainnet.

Reactive Network is the parallelized interoperability execution layer for EVM ecosystems allows AI agents to seamlessly integrate with Web3, enabling them to observe, process, and react to events autonomously, perform machine learning, and create AI-powered dApps, accelerating Web3 AI adoption. The network enhances cross-chain interoperability, enabling DeFi protocols, dApps, and tokens to react to cross-chain events in real time without having to pull data off-chain, paving the way for automated workflows and advanced decentralized derivatives.

Hyperbridge is a cryptoeconomic coprocessor for secure, verifiable interoperability powered by consensus and storage proofs. Hyperbridge is the HTTPS of blockchain interoperability, providing developers with onchain and off-chain SDKs for securely sending cross-chain messages (POST requests) and reading on-chain storage (GET requests).

ValenceZone is a cross-chain protocol enabling programmatic relationships between crypto-native organizations. Valence expands the scope of the IBC Protocol, enabling economic agreements such as adjusting treasury compositions according to market conditions or lending POL.

Holograph is an omnichain tokenization protocol, enabling asset issuers to mint natively composable omnichain tokens. Holograph works by burning tokens on the source chain, sending a message via a messaging protocol to the destination chain, and then reminting the same number of tokens to the same contract address. This unifies liquidity, eliminates slippage, and preserves fungibility across blockchains.

Dante Network is a general middle layer protocol that enables interoperability among multiple chains and integrates diverse resources to empower dApps.

Omni X is an omnichain NFT protocol and marketplace, enabling the growth of the Omniverse ecosystem and community. It provides tools for creating omnichain collections, bridging regular NFTs to ONFTs, and facilitating cross-chain NFT sales. The Omniverse is an ecosystem of community-driven worlds, games, and dApps – the first true metaverse. Here, virtual worlds, users, and protocols deployed on multiple chains can freely communicate and exchange value with each other in a frictionless manner.

MetaEngine provides a platform for interoperability of assets across metaverses.

Counterfactual Network introduces an innovative framework for omni apps, enabling the deployment of genuine cross-chain decentralized applications within the Ethereum ecosystem. In Counterfactual Network, all supported L2s are abstracted into the Unified Execution Layer (UEL). This abstraction simplifies the network architecture, allowing for seamless interaction and execution across multiple L2 platforms.

Openverse is a Layer0 hub network based on blockchain technology. It is based on the existing blockchain technology and proposes the concept of "fully open protocol cross-chain". It will realize "the transmission of value (token/NFT/message) between different blockchains, metaverses and the traditional Internet is as simple as sending email". Openverse has proposed protocol systems such as the "Bitcurrency VRC10 Protocol", "Privcurrency VRC11 Protocol", and "Public Currency Issurance Mechanism, PCIM".

Inclusive Layer is a cross-chain interoperability protocol launched by Delta Blockchain, designed to help people build blockchain applications on multiple chains without deep coding expertise. The first application on Inclusive Layer is a cross-chain transaction service called Caishen.

DeTrading is a trustless cross-chain platform for atomic swaps between all chain.

LayerSync is an innovative blockchain project dedicated to simplifying the minting and transfer of Omnichain Non-Fungible Tokens (ONFTs) within the blockchain ecosystem. The platform serves as a comprehensive solution for minting ONFTs and seamlessly bridging them across a selection of EVM (Ethereum Virtual Machine)-compatible chains.